The Interaction of Atovaquone with the P. carinii Cytochrome bc1 Complex
نویسندگان
چکیده
منابع مشابه
Molecular basis for atovaquone binding to the cytochrome bc1 complex.
Atovaquone is a substituted 2-hydroxynaphthoquinone that is used therapeutically to treat Plasmodium falciparum malaria, Pneumocystis carinii pneumonia, and Toxoplasma gondii toxoplasmosis. It is thought to act on these organisms by inhibiting the cytochrome bc1 complex. We have examined the interaction of atovaquone with the bc1 complex isolated from Saccharomyces cerevisiae, a surrogate, nonp...
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Atovaquone, a substituted hydroxynaphthoquinone, is a potent antimalarial drug that acts by inhibiting the parasite's mitochondrial cytochrome bc1 complex (cyt bc1). Mutations in cyt bc1 confer atovaquone resistance. Here we describe the X-ray structure of mitochondrial cyt bc1 from Saccharomyces cerevisiae with atovaquone bound in the catalytic Qo site, at 3.0-Å resolution. A polarized H-bond ...
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ژورنال
عنوان ژورنال: Journal of Eukaryotic Microbiology
سال: 2001
ISSN: 1066-5234
DOI: 10.1111/j.1550-7408.2001.tb00505.x